科研
邵晨
中国医学科学院基础医学研究所生物信息中心
邵晨,女,助理研究员。2004年毕业于北京大学数学科学学院数学与应用数学专业,获学士学位。同年进入中国医学科学院基础医学研究所攻读研究生,导师为高友鹤教授,2009年博士毕业后留所工作。
研究方向
- 生物质谱数据分析
- 基于组学方法的生物标志物筛选
- 蛋白质相互作用
主持科研项目
- 国家自然基金青年基金:基于靶向蛋白质组学技术的尿蛋白疾病标志物验证筛选平台的建立及其在IgA肾病研究中的应用
- 北京市自然基金:局灶性节段性肾小球硬化诊断标志物的尿蛋白质组学研究
研究成果
- Chen Shao,Yang Zhang, and Wei Sun.(2014) Statistical characterization of HCD fragmentation patterns of tryptic peptides on an LTQ Orbitrap Velos massspectrometer. J Proteomics.23; 109:26-37.
- 邵晨,孙伟。 蛋白质数据库对蛋白质组鉴定的影响.中国生物医学工程学报.2013年32卷卷2期 129-134.
- Xuejiao Liu*, Chen Shao*, Lilong Wei, Jindan Duan, Shuzhen Wu, Xuewang Li, Mingxi Li and Wei Sun.(2012) An individual urinary proteome analysis in normal human beings to define the minimal sample number to represent the normal urinary proteome. Proteome Science 2012, 10:70. (contributed equally)
- Chen Shao, Menglin Li, Xundou Li, Lilong Wei, Lisi Zhu, Fan Yang, Lulu Jia, Yi Mu, Jiangning Wang, Zhengguang Guo, Dan Zhang, Jianrui Yin, Zhigang Wang, Wei Sun, Zhengguo Zhang, and Youhe Gao. (2011) A tool for biomarker discovery in the urinary proteome: a manually curated human and animal urine protein biomarker database. Mol Cell Proteomics. Nov;10(11):M111.010975.
- Chen Shao, Wei Sun, Fuxin Li, Ruifeng Yang, Ling Zhang and Youhe Gao (2009)Oscore: a combined score to reduce false negative rate for peptide identification in tandem mass spectrometry analysis Journal of Mass Spectrometry 44(1):25-31
- Ling Zhang*, Chen Shao*, Dexian Zheng and Youhe Gao (2006)An integrated machine learning system to computationally screen protein databases for Protein binding peptide ligands. Molecular & Cellular Proteomics 5: 1224-1232.(contributed equally)
- Lulu Jia, Ling Zhang, Chen Shao, Eli Song , Wei Sun, Mingxi Li and Youhe Gao. (2009) An attempt to understand kidney’s protein handling function by comparing plasma and urine proteomes. Plos One 4(4):e5146
综述及专著
- Applications of urinary proteomics in biomarker discovery. Sci China Life Sci. 2011 May;54(5):409-17.
- 色谱保留时间在蛋白质组研究中的应用.色谱2010年 第2期 128-134.
- Applications of Peptide Retention Time in Proteomic Data Analysis. Urine Proteomics in Kidney Disease Biomarker Discovery/Advances in Experimental Medicine and Biology Volume 845, 2015, 67-75.
- Urinary Protein Biomarker Database: A Useful Tool for Biomarker Discovery.Urine Proteomics in Kidney Disease Biomarker Discovery/Advances in Experimental Medicine and Biology Volume 845, 2015, 195-203.
教学工作
- 蛋白质组学基础(研究生课程)
- 应用生物信息学(研究生课程)